Geographical Variability in Paromomycin Pharmacokinetics Does Not Explain Efficacy Differences between Eastern African and Indian Visceral Leishmaniasis Patients

INTRODUCTION: Intramuscular paromomycin monotherapy to treat visceral leishmaniasis (VL) has been shown to be effective for Indian patients, while a similar regimen resulted in lower efficacy in Eastern Africa, which could be related to differences in paromomycin pharmacokinetics. METHODS: Pharmacok...

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Detalles Bibliográficos
Autores principales: Verrest, Luka, Wasunna, Monique, Kokwaro, Gilbert, Aman, Rashid, Musa, Ahmed M., Khalil, Eltahir A. G., Mudawi, Mahmoud, Younis, Brima M., Hailu, Asrat, Hurissa, Zewdu, Hailu, Workagegnehu, Tesfaye, Samson, Makonnen, Eyasu, Mekonnen, Yalemtsehay, Huitema, Alwin D. R., Beijnen, Jos H., Kshirsagar, Smita A., Chakravarty, Jaya, Rai, Madhukar, Sundar, Shyam, Alves, Fabiana, Dorlo, Thomas P. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585822/
https://www.ncbi.nlm.nih.gov/pubmed/34105063
http://dx.doi.org/10.1007/s40262-021-01036-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585822/
https://www.ncbi.nlm.nih.gov/pubmed/34105063
http://dx.doi.org/10.1007/s40262-021-01036-8

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