Remodeling tumor microenvironment by liposomal codelivery of DMXAA and simvastatin inhibits malignant melanoma progression

Anti-angiogenic therapies for melanoma have not yet been translated into meaningful clinical benefit for patients, due to the development of drug-induced resistance in cancer cells, mainly caused by hypoxia-inducible factor 1α (HIF-1α) overexpression and enhanced oxidative stress mediated by tumor-a...

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Detalles Bibliográficos
Autores principales: Rauca, Valentin-Florian, Patras, Laura, Luput, Lavinia, Licarete, Emilia, Toma, Vlad-Alexandru, Porfire, Alina, Mot, Augustin Catalin, Rakosy-Tican, Elena, Sesarman, Alina, Banciu, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585864/
https://www.ncbi.nlm.nih.gov/pubmed/34764332
http://dx.doi.org/10.1038/s41598-021-01284-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8585864/
https://www.ncbi.nlm.nih.gov/pubmed/34764332
http://dx.doi.org/10.1038/s41598-021-01284-5

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