A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing

Recent studies have reported that genome editing by CRISPR–Cas9 induces a DNA damage response mediated by p53 in primary cells hampering their growth. This could lead to a selection of cells with pre-existing p53 mutations. In this study, employing an integrated computational and experimental framew...

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Detalles Bibliográficos
Autores principales: Sinha, Sanju, Barbosa, Karina, Cheng, Kuoyuan, Leiserson, Mark D. M., Jain, Prashant, Deshpande, Anagha, Wilson, David M., Ryan, Bríd M., Luo, Ji, Ronai, Ze’ev A., Lee, Joo Sang, Deshpande, Aniruddha J., Ruppin, Eytan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586238/
https://www.ncbi.nlm.nih.gov/pubmed/34764240
http://dx.doi.org/10.1038/s41467-021-26788-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586238/
https://www.ncbi.nlm.nih.gov/pubmed/34764240
http://dx.doi.org/10.1038/s41467-021-26788-6

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