Cryo-EM structure provides insights into the dimer arrangement of the O-linked β-N-acetylglucosamine transferase OGT

The O-linked β-N-acetylglucosamine modification is a core signalling mechanism, with erroneous patterns leading to cancer and neurodegeneration. Although thousands of proteins are subject to this modification, only a single essential glycosyltransferase catalyses its installation, the O-GlcNAc trans...

Descripción completa

Detalles Bibliográficos
Autores principales: Meek, Richard W., Blaza, James N., Busmann, Jil A., Alteen, Matthew G., Vocadlo, David J., Davies, Gideon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586251/
https://www.ncbi.nlm.nih.gov/pubmed/34764280
http://dx.doi.org/10.1038/s41467-021-26796-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586251/
https://www.ncbi.nlm.nih.gov/pubmed/34764280
http://dx.doi.org/10.1038/s41467-021-26796-6

Ejemplares similares