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Cryo-EM structure provides insights into the dimer arrangement of the O-linked β-N-acetylglucosamine transferase OGT

The O-linked β-N-acetylglucosamine modification is a core signalling mechanism, with erroneous patterns leading to cancer and neurodegeneration. Although thousands of proteins are subject to this modification, only a single essential glycosyltransferase catalyses its installation, the O-GlcNAc trans...

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Detalles Bibliográficos
Autores principales:	Meek, Richard W., Blaza, James N., Busmann, Jil A., Alteen, Matthew G., Vocadlo, David J., Davies, Gideon J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586251/ https://www.ncbi.nlm.nih.gov/pubmed/34764280 http://dx.doi.org/10.1038/s41467-021-26796-6

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