Cargando…

Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes

An early event in lung oncogenesis is loss of the tumour suppressor gene LIMD1 (LIM domains containing 1); this encodes a scaffold protein, which suppresses tumorigenesis via a number of different mechanisms. Approximately 45% of non-small cell lung cancers (NSCLC) are deficient in LIMD1, yet this s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Davidson, Kathryn, Grevitt, Paul, Contreras-Gerenas, Maria F., Bridge, Katherine S., Hermida, Miguel, Shah, Kunal M., Mardakheh, Faraz K., Stubbs, Mark, Burke, Rosemary, Casado, Pedro, Cutillas, Pedro R., Martin, Sarah A., Sharp, Tyson V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586256/ https://www.ncbi.nlm.nih.gov/pubmed/34764236 http://dx.doi.org/10.1038/s41419-021-04355-7

Ejemplares similares

A HIF–LIMD1 negative feedback mechanism mitigates the pro‐tumorigenic effects of hypoxia
por: Foxler, Daniel E, et al.
Publicado: (2018)

PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1
por: Foxler, Daniel E., et al.
Publicado: (2011)

LIMD1‐AS1 suppressed non‐small cell lung cancer progression through stabilizing LIMD1 mRNA via hnRNP U
por: Pan, Jianyuan, et al.
Publicado: (2020)

LIMD1 is induced by and required for LMP1 signaling, and protects EBV-transformed cells from DNA damage-induced cell death
por: Wang, Ling, et al.
Publicado: (2017)

AJUBA and WTIP can compete with LIMD1 for junctional localization and LATS regulation
por: Kirichenko, Elmira, et al.
Publicado: (2022)

Upregulation of Biomarker Limd1 Was Correlated with Immune Infiltration in Doxorubicin-Related Cardiotoxicity
por: Zhang, Rui, et al.
Publicado: (2023)

SKI activates the Hippo pathway via LIMD1 to inhibit cardiac fibroblast activation
por: Landry, Natalie M., et al.
Publicado: (2021)

Proteomic Characterization of Acute Myeloid Leukemia for Precision Medicine
por: Casado, Pedro, et al.
Publicado: (2023)

LIMD2 Regulates Key Steps of Metastasis Cascade in Papillary Thyroid Cancer Cells via MAPK Crosstalk
por: Araldi, Rodrigo Pinheiro, et al.
Publicado: (2020)

Super-enhancer-driven lncRNA LIMD1-AS1 activated by CDK7 promotes glioma progression
por: Chen, Zhigang, et al.
Publicado: (2023)

Purification and quantitative proteomic analysis of cell bodies and protrusions
por: Dermit, Maria, et al.
Publicado: (2021)

LIMD1 is a survival prognostic marker of gastric cancer and hinders tumor progression by suppressing activation of YAP1
por: Zhang, Di, et al.
Publicado: (2018)

miR-550a-5p Functions as a Tumor Promoter by Targeting LIMD1 in Lung Adenocarcinoma
por: Guo, Zi-Zhang, et al.
Publicado: (2020)

LIM domain-containing 2 (LIMD2) promotes the progress of ovarian cancer via the focal adhesion signaling pathway
por: Chen, Lixin, et al.
Publicado: (2021)

LIMD2 is a Prognostic and Predictive Marker in Patients With Esophageal Cancer Based on a ceRNA Network Analysis
por: Chen, Yuanmei, et al.
Publicado: (2021)

Novel BRCA2-Interacting Protein, LIMD1, Is Essential for the Centrosome Localization of BRCA2 in Esophageal Cancer Cell
por: Hou, Xiaobin, et al.
Publicado: (2016)

LIMD1 is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications
por: Ghosh, Susmita, et al.
Publicado: (2010)

Algorithm-Based Meta-Analysis Reveals the Mechanistic Interaction of the Tumor Suppressor LIMD1 With Non-Small-Cell Lung Carcinoma
por: Wang, Ling, et al.
Publicado: (2021)

Methods for monitoring and measurement of protein translation in time and space
por: Dermit, Maria, et al.
Publicado: (2017)

LIMD1 Increases the Sensitivity of Lung Adenocarcinoma Cells to Cisplatin via the GADD45α/p38 MAPK Signaling Pathway
por: Zeng, Xiaofei, et al.
Publicado: (2020)

RHO binding to FAM65A regulates Golgi reorientation during cell migration
por: Mardakheh, Faraz K., et al.
Publicado: (2016)

The CKS1/CKS2 Proteostasis Axis Is Crucial to Maintain Hematopoietic Stem Cell Function
por: Grey, William, et al.
Publicado: (2023)

Characterization of a TiO(2) enrichment method for label-free quantitative phosphoproteomics
por: Montoya, Alex, et al.
Publicado: (2011)

eEF2K Activity Determines Synergy to Cotreatment of Cancer Cells With PI3K and MEK Inhibitors
por: Hijazi, Maruan, et al.
Publicado: (2022)

Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling
por: Mardakheh, Faraz K., et al.
Publicado: (2009)

Large-scale models of signal propagation in human cells derived from discovery phosphoproteomic data
por: Terfve, Camille D. A., et al.
Publicado: (2015)

In Silico Analysis Predicts Nuclear Factors NR2F6 and YAP1 as Mesenchymal Subtype-Specific Therapeutic Targets for Ovarian Cancer Patients
por: Kassuhn, Wanja, et al.
Publicado: (2023)

Suppression of AGO2 by miR-132 as a determinant of miRNA-mediated silencing in human primary endothelial cells
por: Leonov, German, et al.
Publicado: (2015)

MicroRNA-155 induction via TNF-α and IFN-γ suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells
por: Yee, Daniel, et al.
Publicado: (2017)

More questions than answers to the diagnosis and management of cauda equina syndrome
por: Patel, Mohammed, et al.
Publicado: (2023)

Differential transmission of the molecular signature of RBSP3, LIMD1 and CDC25A in basal/ parabasal versus spinous of normal epithelium during head and neck tumorigenesis: A mechanistic study
por: Sarkar, Shreya, et al.
Publicado: (2018)

Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins
por: Bridge, Katherine S., et al.
Publicado: (2017)

Factors Secreted by Cancer-Associated Fibroblasts that Sustain Cancer Stem Properties in Head and Neck Squamous Carcinoma Cells as Potential Therapeutic Targets
por: Álvarez-Teijeiro, Saúl, et al.
Publicado: (2018)

Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors
por: Casado, Pedro, et al.
Publicado: (2013)

Systematic identification of biochemical networks in cancer cells by functional pathway inference analysis
por: Badshah, Irbaz I, et al.
Publicado: (2022)

The Deleted in Brachydactyly B Domain of ROR2 Is Required for Receptor Activation by Recruitment of Src
por: Akbarzadeh, Shiva, et al.
Publicado: (2008)

Phosphoproteomics-Based Profiling of Kinase Activities in Cancer Cells
por: Wirbel, Jakob, et al.
Publicado: (2017)

Principles of phosphoproteomics and applications in cancer research
por: Higgins, Luke, et al.
Publicado: (2023)

Global Analysis of mRNA, Translation, and Protein Localization: Local Translation Is a Key Regulator of Cell Protrusions
por: Mardakheh, Faraz K., et al.
Publicado: (2015)

Schober Test and Its Modifications Revisited—What Are We Actually Measuring? Computerized Tomography-Based Analysis
por: Hershkovich, Oded, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hrrosa3t0v50tsf606kmlno7tm