PLZF and its fusion proteins are pomalidomide-dependent CRBN neosubstrates

Pomalidomide and lenalidomide are immunomodulatory agents that were derived from thalidomide. Cereblon (CRBN) is a common direct target of thalidomide and related compounds and works as a Cullin Ring 4 E3 ubiquitin ligase (CRL4) with DDB1, CUL4, and ROC1. The substrate specificity of CRL4(CRBN) is m...

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Detalles Bibliográficos
Autores principales: Shimizu, Nobuyuki, Asatsuma-Okumura, Tomoko, Yamamoto, Junichi, Yamaguchi, Yuki, Handa, Hiroshi, Ito, Takumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586336/
https://www.ncbi.nlm.nih.gov/pubmed/34764413
http://dx.doi.org/10.1038/s42003-021-02801-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586336/
https://www.ncbi.nlm.nih.gov/pubmed/34764413
http://dx.doi.org/10.1038/s42003-021-02801-y

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