A general theoretical framework to design base editors with reduced bystander effects

Base editors (BEs) hold great potential for medical applications of gene therapy. However, high precision base editing requires BEs that can discriminate between the target base and multiple bystander bases within a narrow active window (4 – 10 nucleotides). Here, to assist in the design of these op...

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Detalles Bibliográficos
Autores principales: Wang, Qian, Yang, Jie, Zhong, Zhicheng, Vanegas, Jeffrey A., Gao, Xue, Kolomeisky, Anatoly B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586357/
https://www.ncbi.nlm.nih.gov/pubmed/34764246
http://dx.doi.org/10.1038/s41467-021-26789-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586357/
https://www.ncbi.nlm.nih.gov/pubmed/34764246
http://dx.doi.org/10.1038/s41467-021-26789-5

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