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Structural and Functional Insights Into Skl and Pal Endolysins, Two Cysteine-Amidases With Anti-pneumococcal Activity. Dithiothreitol (DTT) Effect on Lytic Activity
We have structurally and functionally characterized Skl and Pal endolysins, the latter being the first endolysin shown to kill effectively Streptococcus pneumoniae, a leading cause of deathly diseases. We have proved that Skl and Pal are cysteine-amidases whose catalytic domains, from CHAP and Amida...
Autores principales: | Gallego-Páramo, Cristina, Hernández-Ortiz, Noelia, Buey, Rubén M., Rico-Lastres, Palma, García, Guadalupe, Díaz, J. Fernando, García, Pedro, Menéndez, Margarita |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586454/ https://www.ncbi.nlm.nih.gov/pubmed/34777288 http://dx.doi.org/10.3389/fmicb.2021.740914 |
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