Asymmetric Interplay Between K(+) and Blocker and Atomistic Parameters From Physiological Experiments Quantify K(+) Channel Blocker Release

Modulating the activity of ion channels by blockers yields information on both the mode of drug action and on the biophysics of ion transport. Here we investigate the interplay between ions in the selectivity filter (SF) of K(+) channels and the release kinetics of the blocker tetrapropylammonium in...

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Detalles Bibliográficos
Autores principales: Gabriel, Tobias S., Hansen, Ulf-Peter, Urban, Martin, Drexler, Nils, Winterstein, Tobias, Rauh, Oliver, Thiel, Gerhard, Kast, Stefan M., Schroeder, Indra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586521/
https://www.ncbi.nlm.nih.gov/pubmed/34777005
http://dx.doi.org/10.3389/fphys.2021.737834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586521/
https://www.ncbi.nlm.nih.gov/pubmed/34777005
http://dx.doi.org/10.3389/fphys.2021.737834

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