SC75741, A Novel c-Abl Inhibitor, Promotes the Clearance of TDP25 Aggregates via ATG5-Dependent Autophagy Pathway

Abnormal accumulation of TDP43-related mutant proteins in the cytoplasm causes amyotrophic lateral sclerosis (ALS). Herein, unbiased drug screening approaches showed that SC75741, a multi-target inhibitor, inhibited inflammation-induced aggregation by inhibiting NF-κB and also degraded already aggre...

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Detalles Bibliográficos
Autores principales: Zhou, Dongheng, Yan, Huanhuan, Yang, Shuying, Zhang, Yuhong, Xu, Xiaoyan, Cen, Xufeng, Lei, Kai, Xia, Hongguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586708/
https://www.ncbi.nlm.nih.gov/pubmed/34776962
http://dx.doi.org/10.3389/fphar.2021.741219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586708/
https://www.ncbi.nlm.nih.gov/pubmed/34776962
http://dx.doi.org/10.3389/fphar.2021.741219

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