Synthetic vaccine affords full protection to mice against lethal challenge of influenza B virus of both genetic lineages

A quarter of all seasonal influenza cases are caused by type B influenza virus (IBV) that also dominates periodically. Here, we investigated a recombinant adenovirus vaccine carrying a synthetic HA2 representing the consensus sequence of all IBV hemagglutinins. The vaccine fully protected mice from...

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Detalles Bibliográficos
Autores principales: Gravel, Caroline, Muralidharan, Abenaya, Duran, Amparo, Zetner, Adrian, Pfeifle, Annabelle, Zhang, Wanyue, Hashem, Anwar, Tamming, Levi, Farnsworth, Aaron, Loemba, Hugues, Chen, Wangxue, Krammer, Florian, Safronetz, David, Cao, Jingxin, Wang, Lisheng, Sauve, Simon, Rosu-Myles, Michael, Van Domselaar, Gary, Li, Xuguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586812/
https://www.ncbi.nlm.nih.gov/pubmed/34805790
http://dx.doi.org/10.1016/j.isci.2021.103328

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