Molecular Mechanisms Associated with Clustered Lesion-Induced Impairment of 8-oxoG Recognition by the Human Glycosylase OGG1

The 8-oxo-7,8-dihydroguanine, referred to as 8-oxoG, is a highly mutagenic DNA lesion that can provoke the appearance of mismatches if it escapes the DNA Damage Response. The specific recognition of its structural signature by the hOGG1 glycosylase is the first step along the Base Excision Repair pa...

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Detalles Bibliográficos
Autores principales: Jiang, Tao, Monari, Antonio, Dumont, Elise, Bignon, Emmanuelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587150/
https://www.ncbi.nlm.nih.gov/pubmed/34770874
http://dx.doi.org/10.3390/molecules26216465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587150/
https://www.ncbi.nlm.nih.gov/pubmed/34770874
http://dx.doi.org/10.3390/molecules26216465

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