Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA(2)β: Another Contributor to β-Cell Apoptosis in Type 1 Diabetes

Type 1 diabetes (T1D) development, in part, is due to ER stress-induced β-cell apoptosis. Activation of the Ca(2+)-independent phospholipase A(2) beta (iPLA(2)β) leads to the generation of pro-inflammatory eicosanoids, which contribute to β-cell death and T1D. ER stress induces iPLA(2)β-mediated gen...

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Detalles Bibliográficos
Autores principales: Ali, Tomader, Lei, Xiaoyong, Barbour, Suzanne E., Koizumi, Akio, Chalfant, Charles E., Ramanadham, Sasanka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587436/
https://www.ncbi.nlm.nih.gov/pubmed/34770770
http://dx.doi.org/10.3390/molecules26216361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587436/
https://www.ncbi.nlm.nih.gov/pubmed/34770770
http://dx.doi.org/10.3390/molecules26216361

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