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Alterations in β-Cell Sphingolipid Profile Associated with ER Stress and iPLA(2)β: Another Contributor to β-Cell Apoptosis in Type 1 Diabetes
Type 1 diabetes (T1D) development, in part, is due to ER stress-induced β-cell apoptosis. Activation of the Ca(2+)-independent phospholipase A(2) beta (iPLA(2)β) leads to the generation of pro-inflammatory eicosanoids, which contribute to β-cell death and T1D. ER stress induces iPLA(2)β-mediated gen...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587436/ https://www.ncbi.nlm.nih.gov/pubmed/34770770 http://dx.doi.org/10.3390/molecules26216361 |