Structural Optimization and Biological Activity of Pyrazole Derivatives: Virtual Computational Analysis, Recovery Assay and 3D Culture Model as Potential Predictive Tools of Effectiveness against Trypanosoma cruzi

Chagas disease, a chronic and silent disease caused by Trypanosoma cruzi, is currently a global public health problem. The treatment of this neglected disease relies on benznidazole and nifurtimox, two nitroheterocyclic drugs that show limited efficacy and severe side effects. The failure of potenti...

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Detalles Bibliográficos
Autores principales: Orlando, Lorraine Martins Rocha, Lechuga, Guilherme Curty, da Silva Lara, Leonardo, Ferreira, Byanca Silva, Pereira, Cynthia Nathalia, Silva, Rafaela Corrêa, dos Santos, Maurício Silva, Pereira, Mirian Claudia S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587750/
https://www.ncbi.nlm.nih.gov/pubmed/34771151
http://dx.doi.org/10.3390/molecules26216742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587750/
https://www.ncbi.nlm.nih.gov/pubmed/34771151
http://dx.doi.org/10.3390/molecules26216742

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