Preclinical Evaluation of Polymeric Nanocomposite Containing Pregabalin for Sustained Release as Potential Therapy for Neuropathic Pain

This study offers a novel oral pregabalin (PG)-loaded drug delivery system based on chitosan and hypromellose phthalate-based polymeric nanocomposite in order to treat neuropathic pain (PG-PN). PG-PN has a particle size of 432 ± 20 nm, a polydispersity index of 0.238 ± 0.001, a zeta potential of +19...

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Detalles Bibliográficos
Autores principales: Rodrigues, Rafaela Figueiredo, Nunes, Juliana Barbosa, Agostini, Sandra Barbosa Neder, dos Santos, Paloma Freitas, Cancino-Bernardi, Juliana, Placido, Rodrigo Vicentino, Moraes, Thamyris Reis, Freitas, Jennifer Tavares Jacon, Pereira, Gislaine Ribeiro, Carvalho, Flávia Chiva, Galdino, Giovane, Boralli, Vanessa Bergamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587775/
https://www.ncbi.nlm.nih.gov/pubmed/34771392
http://dx.doi.org/10.3390/polym13213837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587775/
https://www.ncbi.nlm.nih.gov/pubmed/34771392
http://dx.doi.org/10.3390/polym13213837

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