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Preclinical Evaluation of Polymeric Nanocomposite Containing Pregabalin for Sustained Release as Potential Therapy for Neuropathic Pain
This study offers a novel oral pregabalin (PG)-loaded drug delivery system based on chitosan and hypromellose phthalate-based polymeric nanocomposite in order to treat neuropathic pain (PG-PN). PG-PN has a particle size of 432 ± 20 nm, a polydispersity index of 0.238 ± 0.001, a zeta potential of +19...
Autores principales: | Rodrigues, Rafaela Figueiredo, Nunes, Juliana Barbosa, Agostini, Sandra Barbosa Neder, dos Santos, Paloma Freitas, Cancino-Bernardi, Juliana, Placido, Rodrigo Vicentino, Moraes, Thamyris Reis, Freitas, Jennifer Tavares Jacon, Pereira, Gislaine Ribeiro, Carvalho, Flávia Chiva, Galdino, Giovane, Boralli, Vanessa Bergamin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587775/ https://www.ncbi.nlm.nih.gov/pubmed/34771392 http://dx.doi.org/10.3390/polym13213837 |
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