A New Class of Uracil–DNA Glycosylase Inhibitors Active against Human and Vaccinia Virus Enzyme

Uracil–DNA glycosylases are enzymes that excise uracil bases appearing in DNA as a result of cytosine deamination or accidental dUMP incorporation from the dUTP pool. The activity of Family 1 uracil–DNA glycosylase (UNG) activity limits the efficiency of antimetabolite drugs and is essential for vir...

Descripción completa

Detalles Bibliográficos
Autores principales: Grin, Inga R., Mechetin, Grigory V., Kasymov, Rustem D., Diatlova, Evgeniia A., Yudkina, Anna V., Shchelkunov, Sergei N., Gileva, Irina P., Denisova, Alexandra A., Stepanov, Grigoriy A., Chilov, Ghermes G., Zharkov, Dmitry O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587785/
https://www.ncbi.nlm.nih.gov/pubmed/34771075
http://dx.doi.org/10.3390/molecules26216668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587785/
https://www.ncbi.nlm.nih.gov/pubmed/34771075
http://dx.doi.org/10.3390/molecules26216668

Ejemplares similares