Total Synthesis of 6-Deoxydihydrokalafungin, a Key Biosynthetic Precursor of Actinorhodin, and Its Epimer

In this article, we report the total synthesis of 6-deoxydihydrokalafungin (DDHK), a key biosynthetic intermediate of a dimeric benzoisochromanequinone antibiotic, actinorhodin (ACT), and its epimer, epi-DDHK. Tricyclic hemiacetal with 3-siloxyethyl group was subjected to Et(3)SiH reduction to estab...

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Detalles Bibliográficos
Autores principales: Kumamoto, Takuya, Kainuma, Mika, Takahashi, Azusa, Matsuo, Yoshika, Katakawa, Kazuaki, Taguchi, Takaaki, Ichinose, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587838/
https://www.ncbi.nlm.nih.gov/pubmed/34770806
http://dx.doi.org/10.3390/molecules26216397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587838/
https://www.ncbi.nlm.nih.gov/pubmed/34770806
http://dx.doi.org/10.3390/molecules26216397

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