Berberine Derivatives as Pseudomonas aeruginosa MexXY-OprM Inhibitors: Activity and In Silico Insights

The natural alkaloid berberine has been demonstrated to inhibit the Pseudomonas aeruginosa multidrug efflux system MexXY-OprM, which is responsible for tobramycin extrusion by binding the inner membrane transporter MexY. To find a structure with improved inhibitory activity, we compared by molecular...

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Detalles Bibliográficos
Autores principales: Giorgini, Giorgia, Mangiaterra, Gianmarco, Cedraro, Nicholas, Laudadio, Emiliano, Sabbatini, Giulia, Cantarini, Mattia, Minnelli, Cristina, Mobbili, Giovanna, Frangipani, Emanuela, Biavasco, Francesca, Galeazzi, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587913/
https://www.ncbi.nlm.nih.gov/pubmed/34771051
http://dx.doi.org/10.3390/molecules26216644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8587913/
https://www.ncbi.nlm.nih.gov/pubmed/34771051
http://dx.doi.org/10.3390/molecules26216644

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