Development of Triazoles and Triazolium Salts Based on AZT and Their Anti-Viral Activity against HIV-1

We report herein a set of 3′-azido-3′-deoxythymidine (AZT) derivatives based on triazoles and triazolium salts for HIV-1 infection. The compounds were synthesized via click chemistry with Cu(I) and Ru(II) catalysts. Triazolium salts were synthesized by reaction with methyl iodide or methyl triflate...

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Detalles Bibliográficos
Autores principales: de Alencar, Daniel Machado, Gonçalves, Juliana, Vieira, Andreia, Cerqueira, Sofia A., Sebastião, Cruz, Leitão, Maria Inês P. S., Francescato, Giulia, Antenori, Paola, Soares, Helena, Petronilho, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588071/
https://www.ncbi.nlm.nih.gov/pubmed/34771129
http://dx.doi.org/10.3390/molecules26216720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588071/
https://www.ncbi.nlm.nih.gov/pubmed/34771129
http://dx.doi.org/10.3390/molecules26216720

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