Isothiourea-Catalyzed Enantioselective α-Alkylation of Esters via 1,6-Conjugate Addition to para-Quinone Methides

The isothiourea-catalyzed enantioselective 1,6-conjugate addition of para-nitrophenyl esters to 2,6-disubstituted para-quinone methides is reported. para-Nitrophenoxide, generated in situ from initial N-acylation of the isothiourea by the para-nitrophenyl ester, is proposed to facilitate catalyst tu...

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Detalles Bibliográficos
Autores principales: Arokianathar, Jude N., Hartley, Will C., McLaughlin, Calum, Greenhalgh, Mark D., Stead, Darren, Ng, Sean, Slawin, Alexandra M. Z., Smith, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588318/
https://www.ncbi.nlm.nih.gov/pubmed/34770741
http://dx.doi.org/10.3390/molecules26216333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588318/
https://www.ncbi.nlm.nih.gov/pubmed/34770741
http://dx.doi.org/10.3390/molecules26216333

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