Cancer-associated MSC drive tumor immune exclusion and resistance to immunotherapy, which can be overcome by Hedgehog inhibition

We investigated the impact of cancer-associated mesenchymal stem cells (CA-MSCs) on ovarian tumor immunity. In patient samples, CA-MSC presence inversely correlates with the presence of intratumoral CD8(+) T cells. Using an immune “hot” mouse ovarian cancer model, we found that CA-MSCs drive CD8(+)...

Descripción completa

Detalles Bibliográficos
Autores principales: Cascio, Sandra, Chandler, Chelsea, Zhang, Linan, Sinno, Sarah, Gao, Bingsi, Onkar, Sayali, Bruno, Tullia C., Vignali, Dario A. A., Mahdi, Haider, Osmanbeyoglu, Hatice U., Vlad, Anda M., Coffman, Lan G., Buckanovich, Ronald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589308/
https://www.ncbi.nlm.nih.gov/pubmed/34767446
http://dx.doi.org/10.1126/sciadv.abi5790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589308/
https://www.ncbi.nlm.nih.gov/pubmed/34767446
http://dx.doi.org/10.1126/sciadv.abi5790

Ejemplares similares