Lactate supports a metabolic-epigenetic link in macrophage polarization

Lactate accumulation is a hallmark of solid cancers and is linked to the immune suppressive phenotypes of tumor-infiltrating immune cells. We report herein that interleukin-4 (IL-4)–induced M0 → M2 macrophage polarization is accompanied by interchangeable glucose- or lactate-dependent tricarboxylic...

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Detalles Bibliográficos
Autores principales: Noe, Jordan T., Rendon, Beatriz E., Geller, Anne E., Conroy, Lindsey R., Morrissey, Samantha M., Young, Lyndsay E.A., Bruntz, Ronald C., Kim, Eun J., Wise-Mitchell, Ashley, Barbosa de Souza Rizzo, Mariana, Relich, Eric R., Baby, Becca V., Johnson, Lance A., Affronti, Hayley C., McMasters, Kelly M., Clem, Brian F., Gentry, Matthew S., Yan, Jun, Wellen, Kathryn E., Sun, Ramon C., Mitchell, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589316/
https://www.ncbi.nlm.nih.gov/pubmed/34767443
http://dx.doi.org/10.1126/sciadv.abi8602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589316/
https://www.ncbi.nlm.nih.gov/pubmed/34767443
http://dx.doi.org/10.1126/sciadv.abi8602

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