MAPK6-AKT signaling promotes tumor growth and resistance to mTOR kinase blockade

Mitogen-activated protein kinase 6 (MAPK6) is an atypical MAPK. Its function in regulating cancer growth remains elusive. Here, we reported that MAPK6 directly activated AKT and induced oncogenic outcomes. MAPK6 interacted with AKT through its C34 region and the C-terminal tail and phosphorylated AK...

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Detalles Bibliográficos
Autores principales: Cai, Qinbo, Zhou, Wolong, Wang, Wei, Dong, Bingning, Han, Dong, Shen, Tao, Creighton, Chad J., Moore, David D., Yang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589317/
https://www.ncbi.nlm.nih.gov/pubmed/34767444
http://dx.doi.org/10.1126/sciadv.abi6439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589317/
https://www.ncbi.nlm.nih.gov/pubmed/34767444
http://dx.doi.org/10.1126/sciadv.abi6439

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