Cargando…

High-resolution structure and dynamics of mitochondrial complex I—Insights into the proton pumping mechanism

Mitochondrial NADH:ubiquinone oxidoreductase (complex I) is a 1-MDa membrane protein complex with a central role in energy metabolism. Redox-driven proton translocation by complex I contributes substantially to the proton motive force that drives ATP synthase. Several structures of complex I from ba...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parey, Kristian, Lasham, Jonathan, Mills, Deryck J., Djurabekova, Amina, Haapanen, Outi, Yoga, Etienne Galemou, Xie, Hao, Kühlbrandt, Werner, Sharma, Vivek, Vonck, Janet, Zickermann, Volker
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589321/ https://www.ncbi.nlm.nih.gov/pubmed/34767441 http://dx.doi.org/10.1126/sciadv.abj3221

Ejemplares similares

Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I
por: Galemou Yoga, Etienne, et al.
Publicado: (2020)

Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling
por: Schiller, Jonathan, et al.
Publicado: (2022)

High-resolution cryo-EM structures of respiratory complex I: Mechanism, assembly, and disease
por: Parey, Kristian, et al.
Publicado: (2019)

Structure of the hexameric fungal plasma membrane proton pump in its autoinhibited state
por: Heit, Sabine, et al.
Publicado: (2021)

Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology
por: Hahn, Alexander, et al.
Publicado: (2016)

Cryo-EM structure of respiratory complex I at work
por: Parey, Kristian, et al.
Publicado: (2018)

Role of Second Quinone Binding Site in Proton Pumping by Respiratory Complex I
por: Haapanen, Outi, et al.
Publicado: (2019)

Ubiquinone Binding and Reduction by Complex I—Open Questions and Mechanistic Implications
por: Galemou Yoga, Etienne, et al.
Publicado: (2021)

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps
por: Cabrera-Orefice, Alfredo, et al.
Publicado: (2018)

Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations
por: Lee, Yongchan, et al.
Publicado: (2022)

Functional asymmetry and electron flow in the bovine respirasome
por: Sousa, Joana S, et al.
Publicado: (2016)

Conformational changes in mitochondrial complex I of the thermophilic eukaryote Chaetomium thermophilum
por: Laube, Eike, et al.
Publicado: (2022)

Role of water and protein dynamics in proton pumping by respiratory complex I
por: Haapanen, Outi, et al.
Publicado: (2017)

Conformational changes in the yeast mitochondrial ABC transporter Atm1 during the transport cycle
por: Ellinghaus, Thomas L., et al.
Publicado: (2021)

Horizontal proton transfer across the antiporter-like subunits in mitochondrial respiratory complex I
por: Zdorevskyi, Oleksii, et al.
Publicado: (2023)

Atomic model of the F(420)-reducing [NiFe] hydrogenase by electron cryo-microscopy using a direct electron detector
por: Allegretti, Matteo, et al.
Publicado: (2014)

The ABC transporter MsbA adopts the wide inward-open conformation in E. coli cells
por: Galazzo, Laura, et al.
Publicado: (2022)

Structure of the SecY Complex Unlocked by a Preprotein Mimic
por: Hizlan, Dilem, et al.
Publicado: (2012)

Lymphatic-draining nanoparticles deliver Bay K8644 payload to lymphatic vessels and enhance their pumping function
por: Sestito, Lauren F., et al.
Publicado: (2023)

Structural basis of proton translocation and force generation in mitochondrial ATP synthase
por: Klusch, Niklas, et al.
Publicado: (2017)

Gating choreography and mechanism of the human proton-activated chloride channel ASOR
por: Wang, Chongyuan, et al.
Publicado: (2022)

pH regulates potassium conductance and drives a constitutive proton current in human TMEM175
por: Zheng, Wang, et al.
Publicado: (2022)

Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I
por: Grba, Daniel N., et al.
Publicado: (2023)

A comparative study of single-particle cryo-EM with liquid-nitrogen and liquid-helium cooling
por: Pfeil-Gardiner, Olivia, et al.
Publicado: (2019)

Structural basis for energy transduction by respiratory alternative complex III
por: Sousa, Joana S., et al.
Publicado: (2018)

Cohesin-dependent chromosome loop extrusion is limited by transcription and stalled replication forks
por: Jeppsson, Kristian, et al.
Publicado: (2022)

Devitrification reduces beam-induced movement in cryo-EM
por: Wieferig, Jan-Philip, et al.
Publicado: (2021)

High-throughput single-cell quantification of hundreds of proteins using conventional flow cytometry and machine learning
por: Becht, Etienne, et al.
Publicado: (2021)

Molecular organization and mechanics of single vimentin filaments revealed by super-resolution imaging
por: Nunes Vicente, Filipe, et al.
Publicado: (2022)

Structure of Alcohol Oxidase from Pichia pastoris by Cryo-Electron Microscopy
por: Vonck, Janet, et al.
Publicado: (2016)

Invasive Staphylococcus epidermidis uses a unique processive wall teichoic acid glycosyltransferase to evade immune recognition
por: Guo, Yinglan, et al.
Publicado: (2023)

Programmable and contractile materials through cell encapsulation in fibrous hydrogel assemblies
por: Davidson, Matthew D., et al.
Publicado: (2021)

An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate
por: Hansen, Stine L., et al.
Publicado: (2023)

Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta)
por: Trimpert, Jakob, et al.
Publicado: (2021)

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine
por: Zhou, Yitian, et al.
Publicado: (2021)

H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway
por: Hansen, Anne Meldgaard, et al.
Publicado: (2022)

ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers
por: Mooz, Juliane, et al.
Publicado: (2022)

Serine protease 35 regulates the fibroblast matrisome in response to hyperosmotic stress
por: Sänger, Catharina S., et al.
Publicado: (2023)

Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex
por: Hurdiss, Daniel L., et al.
Publicado: (2022)

The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases
por: Marullo, Rossella, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1b193vei2o8rai6u8bqs48s7cr