ORMDL3 overexpression facilitates FcεRI‐mediated transcription of proinflammatory cytokines and thapsigargin‐mediated PERK phosphorylation in RBL‐2H3 cells

INTRODUCTION: The chromosomal region 17q21 harbors the human orosomucoid‐like 3 (ORMDL3) gene and has been linked to asthma and other inflammatory diseases. ORMDL3 is involved in the unfolded protein response (UPR), lipid metabolism, and inflammatory reactions. We investigated the effects of ORMDL3...

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Detalles Bibliográficos
Autores principales: Ogi, Kazuhiro, Takabayashi, Tetsuji, Tomita, Kaori, Sakashita, Masafumi, Morikawa, Taiyo, Ninomiya, Takahiro, Okamoto, Masayuki, Narita, Norihiko, Fujieda, Shigeharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589398/
https://www.ncbi.nlm.nih.gov/pubmed/34288557
http://dx.doi.org/10.1002/iid3.489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589398/
https://www.ncbi.nlm.nih.gov/pubmed/34288557
http://dx.doi.org/10.1002/iid3.489

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