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Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer

The discovery of a new class of small molecule compounds that target the BCL-2 family of anti-apoptotic proteins is one of the great success stories of basic science leading to translational outcomes in the last 30 years. The eponymous BCL-2 protein was identified over 30 years ago due to its associ...

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Detalles Bibliográficos
Autores principales: Lee, Erinna F., Fairlie, W. Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589430/
https://www.ncbi.nlm.nih.gov/pubmed/34515749
http://dx.doi.org/10.1042/BST20210749