Cargando…
Discovery, development and application of drugs targeting BCL-2 pro-survival proteins in cancer
The discovery of a new class of small molecule compounds that target the BCL-2 family of anti-apoptotic proteins is one of the great success stories of basic science leading to translational outcomes in the last 30 years. The eponymous BCL-2 protein was identified over 30 years ago due to its associ...
Autores principales: | Lee, Erinna F., Fairlie, W. Douglas |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589430/ https://www.ncbi.nlm.nih.gov/pubmed/34515749 http://dx.doi.org/10.1042/BST20210749 |
Ejemplares similares
-
Co-Operativity between MYC and BCL-2 Pro-Survival Proteins in Cancer
por: Fairlie, Walter Douglas, et al.
Publicado: (2021) -
Targeting the BCL-2-regulated apoptotic pathway for the treatment of solid cancers
por: Fairlie, W. Douglas, et al.
Publicado: (2021) -
The Structural Biology of Bcl-x(L)
por: Lee, Erinna F., et al.
Publicado: (2019) -
BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival
por: Lee, Erinna F., et al.
Publicado: (2019) -
BECLIN1: Protein Structure, Function and Regulation
por: Tran, Sharon, et al.
Publicado: (2021)