Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy

Calpain proteolysis contributes to the pathogenesis of heart failure but the calpain isoforms responsible and their substrate specificities have not been rigorously defined. One substrate, Junctophilin-2 (JP2), is essential for maintaining junctional cardiac dyads and excitation-contraction coupling...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jinxi, Ciampa, Grace, Zheng, Dong, Shi, Qian, Chen, Biyi, Abel, E. Dale, Peng, Tianqing, Hall, Duane D., Song, Long-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Cardiovascular System & Vascular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589432/
https://www.ncbi.nlm.nih.gov/pubmed/34524407
http://dx.doi.org/10.1042/BCJ20210629

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589432/
https://www.ncbi.nlm.nih.gov/pubmed/34524407
http://dx.doi.org/10.1042/BCJ20210629

Ejemplares similares