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Calpain-2 specifically cleaves Junctophilin-2 at the same site as Calpain-1 but with less efficacy
Calpain proteolysis contributes to the pathogenesis of heart failure but the calpain isoforms responsible and their substrate specificities have not been rigorously defined. One substrate, Junctophilin-2 (JP2), is essential for maintaining junctional cardiac dyads and excitation-contraction coupling...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Portland Press Ltd.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589432/ https://www.ncbi.nlm.nih.gov/pubmed/34524407 http://dx.doi.org/10.1042/BCJ20210629 |