Clozapine modulates retinoid homeostasis in human brain and normalizes serum retinoic acid deficit in patients with schizophrenia

The atypical antipsychotic clozapine is one of the most potent drugs of its class, yet its precise mechanisms of action remain insufficiently understood. Recent evidence points toward the involvement of endogenous retinoic acid (RA) signaling in the pathophysiology of schizophrenia. Here we investig...

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Detalles Bibliográficos
Autores principales: Regen, Francesca, Cosma, Nicoleta-Carmen, Otto, Lisa R., Clemens, Vera, Saksone, Lana, Gellrich, Janine, Uesekes, Berk, Ta, Thi Minh Tam, Hahn, Eric, Dettling, Michael, Heuser, Isabella, Hellmann-Regen, Julian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589649/
https://www.ncbi.nlm.nih.gov/pubmed/32488128
http://dx.doi.org/10.1038/s41380-020-0791-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589649/
https://www.ncbi.nlm.nih.gov/pubmed/32488128
http://dx.doi.org/10.1038/s41380-020-0791-8

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