MRPS31 loss is a key driver of mitochondrial deregulation and hepatocellular carcinoma aggressiveness

ABSTRACT: Deregulated mitochondrial energetics is a metabolic hallmark of cancer cells. However, the causative mechanism of the bioenergetic deregulation is not clear. In this study, we show that somatic copy number alteration (SCNA) of mitoribosomal protein (MRP) genes is a key mechanism of bioener...

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Detalles Bibliográficos
Autores principales: Min, Seongki, Lee, Young-Kyoung, Hong, Jiwon, Park, Tae Jun, Woo, Hyun Goo, Kwon, So Mee, Yoon, Gyesoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589861/
https://www.ncbi.nlm.nih.gov/pubmed/34772924
http://dx.doi.org/10.1038/s41419-021-04370-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589861/
https://www.ncbi.nlm.nih.gov/pubmed/34772924
http://dx.doi.org/10.1038/s41419-021-04370-8

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