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MRPS31 loss is a key driver of mitochondrial deregulation and hepatocellular carcinoma aggressiveness
ABSTRACT: Deregulated mitochondrial energetics is a metabolic hallmark of cancer cells. However, the causative mechanism of the bioenergetic deregulation is not clear. In this study, we show that somatic copy number alteration (SCNA) of mitoribosomal protein (MRP) genes is a key mechanism of bioener...
Autores principales: | Min, Seongki, Lee, Young-Kyoung, Hong, Jiwon, Park, Tae Jun, Woo, Hyun Goo, Kwon, So Mee, Yoon, Gyesoon |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589861/ https://www.ncbi.nlm.nih.gov/pubmed/34772924 http://dx.doi.org/10.1038/s41419-021-04370-8 |
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