Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

Despite the strong evidence linking the aggregation of the Huntingtin protein (Htt) to the pathogenesis of Huntington’s disease (HD), the mechanisms underlying Htt aggregation and neurodegeneration remain poorly understood. Herein, we investigated the ultrastructural properties and protein compositi...

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Detalles Bibliográficos
Autores principales: Riguet, Nathan, Mahul-Mellier, Anne-Laure, Maharjan, Niran, Burtscher, Johannes, Croisier, Marie, Knott, Graham, Hastings, Janna, Patin, Alice, Reiterer, Veronika, Farhan, Hesso, Nasarov, Sergey, Lashuel, Hilal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589980/
https://www.ncbi.nlm.nih.gov/pubmed/34772920
http://dx.doi.org/10.1038/s41467-021-26684-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589980/
https://www.ncbi.nlm.nih.gov/pubmed/34772920
http://dx.doi.org/10.1038/s41467-021-26684-z

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