Computational redesign of Fab CC12.3 with substantially better predicted binding affinity to SARS-CoV-2 than human ACE2 receptor

SARS-CoV-2 is responsible for COVID-19 pandemic, causing large numbers of cases and deaths. It initiates entry into human cells by binding to the peptidase domain of angiotensin-converting enzyme 2 (ACE2) receptor via its receptor binding domain of S1 subunit of spike protein (SARS-CoV-2-RBD). Emplo...

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Detalles Bibliográficos
Autores principales: Treewattanawong, Wantanee, Sitthiyotha, Thassanai, Chunsrivirot, Surasak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590000/
https://www.ncbi.nlm.nih.gov/pubmed/34772947
http://dx.doi.org/10.1038/s41598-021-00684-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590000/
https://www.ncbi.nlm.nih.gov/pubmed/34772947
http://dx.doi.org/10.1038/s41598-021-00684-x

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