WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells

The tumor suppressor BRCA2 protects stalled forks from degradation to maintain genome stability. However, the molecular mechanism(s) whereby unprotected forks are stabilized remains to be fully characterized. Here, we demonstrate that WRN helicase ensures efficient restart and limits excessive degra...

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Detalles Bibliográficos
Autores principales: Datta, Arindam, Biswas, Kajal, Sommers, Joshua A., Thompson, Haley, Awate, Sanket, Nicolae, Claudia M., Thakar, Tanay, Moldovan, George-Lucian, Shoemaker, Robert H., Sharan, Shyam K., Brosh, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590011/
https://www.ncbi.nlm.nih.gov/pubmed/34772932
http://dx.doi.org/10.1038/s41467-021-26811-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590011/
https://www.ncbi.nlm.nih.gov/pubmed/34772932
http://dx.doi.org/10.1038/s41467-021-26811-w

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