The RNA-binding protein HuR is required for maintenance of the germinal centre response

The germinal centre (GC) is required for the generation of high affinity antibodies and immunological memory. Here we show that the RNA binding protein HuR has an essential function in GC B cells to sustain the GC response. In its absence, the GC reaction and production of high-affinity antibody is...

Descripción completa

Detalles Bibliográficos
Autores principales: Osma-Garcia, Ines C., Capitan-Sobrino, Dunja, Mouysset, Mailys, Bell, Sarah E., Lebeurrier, Manuel, Turner, Martin, Diaz-Muñoz, Manuel D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590059/
https://www.ncbi.nlm.nih.gov/pubmed/34772950
http://dx.doi.org/10.1038/s41467-021-26908-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590059/
https://www.ncbi.nlm.nih.gov/pubmed/34772950
http://dx.doi.org/10.1038/s41467-021-26908-2

Ejemplares similares