The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability

The target of Rapamycin complex1 (TORC1) senses and integrates several environmental signals, including amino acid (AA) availability, to regulate cell growth. Folliculin (FLCN) is a tumor suppressor (TS) protein in renal cell carcinoma, which paradoxically activates TORC1 in response to AA supplemen...

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Detalles Bibliográficos
Autores principales: Calvo, Isabel A., Sharma, Shalini, Paulo, Joao A., Gulka, Alexander O.D., Boeszoermenyi, Andras, Zhang, Jingyu, Lombana, Jose M., Palmieri, Christina M., Laviolette, Laura A., Arthanari, Haribabu, Iliopoulos, Othon, Gygi, Steven P., Motamedi, Mo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590082/
https://www.ncbi.nlm.nih.gov/pubmed/34805795
http://dx.doi.org/10.1016/j.isci.2021.103338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590082/
https://www.ncbi.nlm.nih.gov/pubmed/34805795
http://dx.doi.org/10.1016/j.isci.2021.103338

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