CDK2 phosphorylation of Werner protein (WRN) contributes to WRN’s DNA double‐strand break repair pathway choice

Werner syndrome (WS) is an accelerated aging disorder characterized by genomic instability, which is caused by WRN protein deficiency. WRN participates in DNA metabolism including DNA repair. In a previous report, we showed that WRN protein is recruited to laser‐induced DNA double‐strand break (DSB)...

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Detalles Bibliográficos
Autores principales: Lee, Jong‐Hyuk, Shamanna, Raghavendra A., Kulikowicz, Tomasz, Borhan Fakouri, Nima, Kim, Edward W., Christiansen, Louise S., Croteau, Deborah L., Bohr, Vilhelm A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590104/
https://www.ncbi.nlm.nih.gov/pubmed/34612580
http://dx.doi.org/10.1111/acel.13484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590104/
https://www.ncbi.nlm.nih.gov/pubmed/34612580
http://dx.doi.org/10.1111/acel.13484

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