Intravitreal HDAC Inhibitor Belinostat Effectively Eradicates Vitreous Seeds Without Retinal Toxicity In Vivo in a Rabbit Retinoblastoma Model

PURPOSE: Current melphalan-based regimens for intravitreal chemotherapy for retinoblastoma vitreous seeds are effective but toxic to the retina. Thus, alternative agents are needed. Based on the known biology of histone deacetylases (HDACs) in the retinoblastoma pathway, we systematically studied wh...

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Detalles Bibliográficos
Autores principales: Kaczmarek, Jessica V., Bogan, Carley M., Pierce, Janene M., Tao, Yuankai K., Chen, Sheau-Chiann, Liu, Qi, Liu, Xiao, Boyd, Kelli L., Calcutt, M. Wade, Bridges, Thomas M., Lindsley, Craig W., Friedman, Debra L., Richmond, Ann, Daniels, Anthony B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Anatomy and Pathology/Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590161/
https://www.ncbi.nlm.nih.gov/pubmed/34757417
http://dx.doi.org/10.1167/iovs.62.14.8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590161/
https://www.ncbi.nlm.nih.gov/pubmed/34757417
http://dx.doi.org/10.1167/iovs.62.14.8

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