Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action

Ketamine is a noncompetitive glutamatergic N-methyl-d-aspartate receptor (NMDAR) antagonist that exerts rapid antidepressant effects. Preclinical studies identify eukaryotic elongation factor 2 kinase (eEF2K) signaling as essential for the rapid antidepressant action of ketamine. Here, we combine ge...

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Detalles Bibliográficos
Autores principales: Suzuki, Kanzo, Kim, Ji-Woon, Nosyreva, Elena, Kavalali, Ege T., Monteggia, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590465/
https://www.ncbi.nlm.nih.gov/pubmed/34731624
http://dx.doi.org/10.1016/j.celrep.2021.109918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590465/
https://www.ncbi.nlm.nih.gov/pubmed/34731624
http://dx.doi.org/10.1016/j.celrep.2021.109918

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