The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells

N-terminal HSP90 inhibitors in development have had issues arising from heat shock response (HSR) induction and off-target effects. We sought to investigate the capacity of NCT-58, a rationally-synthesized C-terminal HSP90 inhibitor, to kill trastuzumab-resistant HER2-positive breast cancer stem-lik...

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Detalles Bibliográficos
Autores principales: Park, Soeun, Kim, Yoon-Jae, Park, Jung Min, Park, Minsu, Nam, Kee Dal, Farrand, Lee, Nguyen, Cong-Truong, La, Minh Thanh, Ann, Jihyae, Lee, Jeewoo, Kim, Ji Young, Seo, Jae Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590693/
https://www.ncbi.nlm.nih.gov/pubmed/34775489
http://dx.doi.org/10.1038/s41420-021-00743-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590693/
https://www.ncbi.nlm.nih.gov/pubmed/34775489
http://dx.doi.org/10.1038/s41420-021-00743-2

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