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The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells

N-terminal HSP90 inhibitors in development have had issues arising from heat shock response (HSR) induction and off-target effects. We sought to investigate the capacity of NCT-58, a rationally-synthesized C-terminal HSP90 inhibitor, to kill trastuzumab-resistant HER2-positive breast cancer stem-lik...

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Detalles Bibliográficos
Autores principales:	Park, Soeun, Kim, Yoon-Jae, Park, Jung Min, Park, Minsu, Nam, Kee Dal, Farrand, Lee, Nguyen, Cong-Truong, La, Minh Thanh, Ann, Jihyae, Lee, Jeewoo, Kim, Ji Young, Seo, Jae Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590693/ https://www.ncbi.nlm.nih.gov/pubmed/34775489 http://dx.doi.org/10.1038/s41420-021-00743-2

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