Exosomal tau with seeding activity is released from Alzheimer’s disease synapses, and seeding potential is associated with amyloid beta

Synaptic transfer of tau has long been hypothesized from the human pathology pattern and has been demonstrated in vitro and in vivo, but the precise mechanisms remain unclear. Extracellular vesicles such as exosomes have been suggested as a mechanism, but not all tau is exosomal. The present experim...

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Detalles Bibliográficos
Autores principales: Miyoshi, Emily, Bilousova, Tina, Melnik, Mikhail, Fakhrutdinov, Danyl, Poon, Wayne W., Vinters, Harry V., Miller, Carol A., Corrada, Maria, Kawas, Claudia, Bohannan, Ryan, Caraway, Chad, Elias, Chris, Maina, Katherine N., Campagna, Jesus J., John, Varghese, Gylys, Karen Hoppens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590975/
https://www.ncbi.nlm.nih.gov/pubmed/34462532
http://dx.doi.org/10.1038/s41374-021-00644-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590975/
https://www.ncbi.nlm.nih.gov/pubmed/34462532
http://dx.doi.org/10.1038/s41374-021-00644-z

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