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Exosomal tau with seeding activity is released from Alzheimer’s disease synapses, and seeding potential is associated with amyloid beta
Synaptic transfer of tau has long been hypothesized from the human pathology pattern and has been demonstrated in vitro and in vivo, but the precise mechanisms remain unclear. Extracellular vesicles such as exosomes have been suggested as a mechanism, but not all tau is exosomal. The present experim...
Autores principales: | Miyoshi, Emily, Bilousova, Tina, Melnik, Mikhail, Fakhrutdinov, Danyl, Poon, Wayne W., Vinters, Harry V., Miller, Carol A., Corrada, Maria, Kawas, Claudia, Bohannan, Ryan, Caraway, Chad, Elias, Chris, Maina, Katherine N., Campagna, Jesus J., John, Varghese, Gylys, Karen Hoppens |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8590975/ https://www.ncbi.nlm.nih.gov/pubmed/34462532 http://dx.doi.org/10.1038/s41374-021-00644-z |
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