Targeting CDK5 in Astrocytes Promotes Calcium Homeostasis Under Excitotoxic Conditions

Glutamate excitotoxicity triggers overactivation of CDK5 and increases calcium influx in neural cells, which promotes dendritic retraction, spine loss, increased mitochondrial calcium from the endoplasmic reticulum, and neuronal death. Our previous studies showed that CDK5 knockdown (KD) in astrocyt...

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Detalles Bibliográficos
Autores principales: Toro-Fernández, Luisa Fernanda, Zuluaga-Monares, Juan Camilo, Saldarriaga-Cartagena, Ana María, Cardona-Gómez, Gloria Patricia, Posada-Duque, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591049/
https://www.ncbi.nlm.nih.gov/pubmed/34790098
http://dx.doi.org/10.3389/fncel.2021.643717

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591049/
https://www.ncbi.nlm.nih.gov/pubmed/34790098
http://dx.doi.org/10.3389/fncel.2021.643717

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