Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome

BACKGROUND: Tumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase system. We investigated the role of MG and Glo1 in cancer chemotherapy related in...

Descripción completa

Detalles Bibliográficos
Autores principales: Alhujaily, Muhanad, Abbas, Hafsa, Xue, Mingzhan, de la Fuente, Alberto, Rabbani, Naila, Thornalley, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591171/
https://www.ncbi.nlm.nih.gov/pubmed/34790575
http://dx.doi.org/10.3389/fonc.2021.748698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591171/
https://www.ncbi.nlm.nih.gov/pubmed/34790575
http://dx.doi.org/10.3389/fonc.2021.748698

Ejemplares similares