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Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome

BACKGROUND: Tumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase system. We investigated the role of MG and Glo1 in cancer chemotherapy related in...

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Detalles Bibliográficos
Autores principales:	Alhujaily, Muhanad, Abbas, Hafsa, Xue, Mingzhan, de la Fuente, Alberto, Rabbani, Naila, Thornalley, Paul J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8591171/ https://www.ncbi.nlm.nih.gov/pubmed/34790575 http://dx.doi.org/10.3389/fonc.2021.748698

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